When Pregnancy Loss Happens More Than Once, Answers Matter
Losing a pregnancy once is heartbreaking. Losing a pregnancy two or three times in a row raises a much harder question: is something treatable happening beneath the surface?
Recurrent Pregnancy Loss, commonly abbreviated as RPL, is defined as two or more consecutive pregnancy losses. While a single miscarriage is often unexplained and unlikely to repeat, recurrent loss frequently points toward an underlying immune, hormonal, genetic, or clotting factor that can be identified through targeted testing.
This is exactly why the RPL Panel exists. Rather than testing one factor in isolation, it evaluates eight essential systems together, giving couples and their doctors a complete picture in a single comprehensive workup. At Altus Lab, the RPL Panel is priced at ₹34,500, against an MRP of ₹45,000, and every report is reviewed under the supervision of expert pathologists.
What Is the RPL Panel?
The RPL Panel is a comprehensive diagnostic panel designed specifically for couples experiencing recurrent pregnancy loss. Instead of ordering multiple individual tests separately across different visits, this panel consolidates eight clinically essential tests into one streamlined evaluation, covering infection screening, hormonal function, autoimmune markers, clotting disorders, and genetic factors.
Because pregnancy loss can stem from several different underlying mechanisms, testing only one area often leaves the real cause undiscovered. The RPL Panel addresses this gap directly, offering a comprehensive evaluation of key immune, hormonal, metabolic, and clotting factors in a single sample collection process.
The 8 Essential Tests Included in the RPL Panel
1. TORCH Profile
Screens for Toxoplasma, Rubella, Cytomegalovirus, and Herpes infections, all of which can silently affect pregnancy outcomes if present and undetected.
2. Homocysteine
Elevated homocysteine levels are linked to impaired blood vessel function and placental blood flow, and are frequently found in women experiencing recurrent pregnancy loss.
3. Thyroid Function Test (TFT) + Anti-TPO Antibody
Thyroid imbalance, along with autoimmune thyroid antibodies, is one of the most common and most treatable contributors to pregnancy loss, making this a foundational test in the panel.
4. ANA / APLA Panel
Antinuclear Antibody and Antiphospholipid Antibody testing identifies autoimmune conditions where the body’s immune system may inadvertently affect pregnancy maintenance.
5. Protein C / Protein S / Antithrombin III / Factor V Leiden / MTHFR Mutation / Factor II Mutation
This cluster of tests evaluates inherited clotting disorders, collectively known as thrombophilia markers, which can increase the risk of placental blood clots and subsequent pregnancy loss.
6. Coagulation Profile
Provides a broader assessment of the blood’s overall clotting function, complementing the specific thrombophilia markers above.
7. Karyotyping (Chromosomal Analysis)
Examines the chromosomal structure of both partners, since chromosomal rearrangements, even when the parents are otherwise healthy, can be a significant and often overlooked cause of recurrent loss.
8. FRAT (Folate Receptor Antibody Test) / Anti-FOLR1 Antibody (ELISA)
Detects autoantibodies that block folate receptors, a mechanism increasingly studied in relation to pregnancy complications and neural tube development, alongside its established role in neurological research.
Why This Combination of Tests Matters
Each test in the RPL Panel examines a distinct biological system, yet pregnancy loss rarely stems from a single isolated cause. Consequently, evaluating all eight factors together gives your doctor a genuinely comprehensive picture rather than a partial one.
For instance, a woman with an undiagnosed thyroid imbalance may also carry a clotting factor mutation, and neither finding alone would fully explain her history without the other. Similarly, chromosomal factors identified through karyotyping often require an entirely different management approach compared to an autoimmune or infectious cause. By testing broadly upfront, couples avoid the frustrating cycle of repeated single-test visits, each yielding inconclusive answers.
Who Should Get the RPL Panel Done?
The RPL Panel is specifically recommended for couples and individuals in the following situations:
- Two or more consecutive pregnancy losses, whether early or later in pregnancy
- Unexplained infertility alongside a history of pregnancy loss
- A previous pregnancy affected by growth restriction or unexplained complications
- Family history of clotting disorders or autoimmune conditions
- Couples planning conception after experiencing prior pregnancy loss, seeking preconception clarity
Furthermore, many fertility specialists recommend this panel proactively before starting IVF or other assisted reproduction protocols, since identifying a treatable cause beforehand often improves the likelihood of a successful pregnancy.
RPL Panel Cost in India — Altus Lab Pricing
| Provider | RPL Panel Price |
|---|---|
| Standard MRP (Individual Test Booking) | ₹45,000 |
| Altus Lab — Comprehensive RPL Panel | ₹34,500 |
At ₹34,500, Altus Lab offers the complete 8-test RPL Panel at a meaningful saving compared to booking each test individually, without any compromise in accuracy or reporting quality. This pricing reflects a genuine commitment to making comprehensive reproductive health testing accessible to families across India.
Why Altus Lab Is a Leading Choice for the RPL Panel in India
Comprehensive Evaluation in One Panel
Rather than visiting multiple labs or ordering scattered individual tests, Altus Lab consolidates all eight essential evaluations into one coordinated panel, saving both time and repeated sample collection.
Helps Identify Underlying, Treatable Causes
Many causes of recurrent pregnancy loss identified through this panel, including thyroid imbalance, clotting factor mutations, and autoimmune markers, are directly treatable once properly diagnosed.
Useful for Preconception Planning
Couples planning their next pregnancy, or preparing for fertility treatment, benefit significantly from completing this panel beforehand, allowing personalised treatment planning ahead of conception.
Detailed, Accurate Reports by Expert Pathologists
Every result in the RPL Panel is reviewed by experienced pathologists before release, ensuring your report reflects genuine clinical accuracy rather than raw, unreviewed data.
Home Sample Collection Available
Altus Lab offers home sample collection, allowing couples to complete this comprehensive panel without the added stress of multiple clinic visits during an already emotionally difficult time.
How the RPL Panel Process Works
Booking the RPL Panel follows a straightforward process from start to finish. First, you schedule your appointment by phone, WhatsApp, or by scanning the booking QR code available on our materials. Next, a trained professional collects the required blood sample, either at our Chandigarh facility or through home collection. The sample then undergoes analysis across all eight test categories using validated laboratory methodology. Finally, your consolidated report is reviewed by our expert pathology team before being delivered to you and, if you choose, directly shared with your treating gynaecologist or fertility specialist.
What Happens After Your RPL Panel Results?
Once your results are ready, share the complete report with your gynaecologist or fertility specialist for interpretation. If a specific cause is identified, such as thyroid dysfunction, a clotting factor mutation, or an autoimmune marker, your doctor can recommend targeted treatment before your next pregnancy attempt. If karyotyping reveals a chromosomal factor, genetic counselling can help clarify your options moving forward.
Even when results fall within normal ranges across all eight tests, this outcome still provides valuable reassurance, allowing your doctor to explore other avenues with greater confidence and clarity.
Book Your RPL Panel Today
Early, comprehensive testing after recurrent pregnancy loss can meaningfully change the outlook for your next pregnancy. Rather than facing repeated uncertainty, the RPL Panel offers a structured path toward clear answers and, where possible, an actionable treatment plan.
📞 Call: 0172-5017001 / 0172-5017002
💬 WhatsApp: +91-62842-14977
📍 SCO 35, Sector 16-D, Chandigarh (Opp. Post Office, Near PGI)
🌐 www.altuslab.in
Frequently Asked Questions
1. What is the RPL Panel?The RPL Panel, or Recurrent Pregnancy Loss Panel, is a comprehensive diagnostic evaluation covering eight essential tests, including TORCH profile, homocysteine, thyroid function, autoimmune markers, clotting factors, karyotyping, and FRAT antibody testing, designed to identify underlying causes of recurrent pregnancy loss.
2. What is the RPL Panel cost in India?
The RPL Panel is priced at ₹34,500 at Altus Lab, compared to an MRP of ₹45,000 when tests are booked individually, offering couples a comprehensive and cost-effective evaluation in one panel.
3. How many pregnancy losses qualify as recurrent pregnancy loss?
Recurrent Pregnancy Loss is generally defined as two or more consecutive pregnancy losses, though your doctor may recommend testing after the first loss depending on your individual history.
4. Which tests are included in the RPL Panel?
The panel includes TORCH Profile, Homocysteine, Thyroid Function Test with Anti-TPO Antibody, ANA/APLA Panel, Protein C, Protein S, Antithrombin III, Factor V Leiden, MTHFR Mutation, Factor II Mutation, Coagulation Profile, Karyotyping, and FRAT/Anti-FOLR1 Antibody testing.
5. Is home sample collection available for the RPL Panel?
Yes. Altus Lab offers home sample collection for the RPL Panel, allowing couples to complete comprehensive testing conveniently and comfortably.
6. Should both partners get tested?
Karyotyping, in particular, is often recommended for both partners, since chromosomal factors from either partner can contribute to recurrent pregnancy loss. Your doctor can guide which specific tests within the panel apply to each partner.
7. Can the RPL Panel help before starting IVF treatment?
Yes. Many fertility specialists recommend the RPL Panel before starting IVF or other assisted reproduction protocols, since identifying a treatable underlying cause beforehand often improves overall treatment outcomes.
8. Who reviews the RPL Panel results at Altus Lab?
All RPL Panel results at Altus Lab are reviewed by our expert pathology team before release, ensuring detailed, accurate, and clinically meaningful reporting for every patient.